Psoriasis is a chronic recurrent disease form of erythematous macular lesion firmly bounded, covered by the roughcoated squama, translucent white and accompanied by the Koebner phenomenon and Auspitz sign. The aim of this study was to analyze prescription profile for drug utilization in psoriasis patients using World Health Organization core indicators. A prospective observational drug utilization study was conducted in dermatology outpatient department of Tertiary care Hospital, in south India for 6 months (January-July 2014) (N = 44). The results of this study showed that the primary therapy used in patient psoriasis that have severity degrees (moderate to severe) were corticosteroids, antibiotics, retinoids and skin care. Dapsone as antibiotic which was used on 61.36% of all patients, sytemic corticosteroid which was widely used is prednisolone and clofazamine (61.36 and 38.63%) and skin care treatment used was paraffin (100%). Besides, the supportive therapy was given to psoriasis patients include antihistamines (hydroxyzine), ferrous sulphate, antiemetic agent (ondansetron), etc. The drug utilization auditing should be conducted for rational prescription, reduce medication errors and effective management in psoriasis patients.
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